BDBM50315283 CHEMBL1090210::N-((6aR,8R,10aS)-10a-(4-chlorophenylsulfonyl)-1,4-difluoro-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-8-yl)cyclopropanesulfonamide::US8569521, 806

SMILES Fc1ccc(F)c2c1OC[C@H]1C[C@@H](CC[C@@]21S(=O)(=O)c1ccc(Cl)cc1)NS(=O)(=O)C1CC1

InChI Key InChIKey=VAAPJDSRZCMKSZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315283   

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50315283(CHEMBL1090210 | US8569521, 806 | N-((6aR,8R,10aS)-...)
Affinity DataIC50: 8nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50315283(CHEMBL1090210 | US8569521, 806 | N-((6aR,8R,10aS)-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed