BDBM50315082 (R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea::CHEMBL1092046

SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2CCOC[C@H]2C)C2CCOCC2)cc1

InChI Key InChIKey=VYYATPJQKLXUAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50315082   

TargetSerine/threonine-protein kinase mTOR(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed