BDBM50315003 CHEMBL1092227::N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)benzamide

SMILES Nc1cccc(Cn2c(ccc2-c2ccc(cc2)C(=O)NCC=C)-c2ccccc2)n1

InChI Key InChIKey=LLAHJUDHJREWBP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50315003   

TargetBeta-secretase 1(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataIC50: 4.36E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed