BDBM50314989 CHEMBL1092250::N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine

SMILES COc1cc2nccc(Nc3cccc(c3)C#C)c2cc1OC

InChI Key InChIKey=WMAOMQUWVSXRPR-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314989   

TargetEpidermal growth factor receptor(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataIC50: 500nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataKd:  0.270nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chemical Genomics Centre of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314989(N-(3-Ethynylphenyl)-6,7-dimethoxyquinolin-4-amine ...)
Affinity DataIC50: 42nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed