BDBM50314965 4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl)-4,5-difluorobiphenyl-2-carboxylic acid::CHEMBL1092730

SMILES OC(=O)c1cc(F)c(F)cc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1

InChI Key InChIKey=WRTOIQWQOCBQCT-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314965   

TargetBombesin receptor subtype-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314965(4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl...)
Affinity DataIC50: 36nMAssay Description:Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBombesin receptor subtype-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314965(4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBombesin receptor subtype-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314965(4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl...)
Affinity DataEC50:  103nMAssay Description:Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBombesin receptor subtype-3(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314965(4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl...)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBombesin receptor subtype-3(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314965(4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed