BDBM50314924 6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)spiro[chroman-2,4'-piperidin]-4-one::CHEMBL1091588

SMILES Cc1cc(cc2c1[nH]nc2)C(=O)N3CCC4(CC3)CC(=O)c5cc(c(cc5O4)C)C

InChI Key InChIKey=PQQBCUZITMWICX-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314924   

TargetAcetyl-CoA carboxylase 1(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50: 25nMAssay Description:Inhibition of rat recombinant ACC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50: 22nMAssay Description:Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314924(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed