BDBM50314838 3'-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine::CHEMBL1090134

SMILES Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)n2cc(CC3CCCC3)nn2)c(=O)[nH]c1=O

InChI Key InChIKey=DXQTXFIMYPXSKO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314838   

TargetThymidine kinase 2, mitochondrial(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314838(3'-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deo...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant mitochondrial thymidine kinase 2 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314838(3'-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deo...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of HSV1 thymidine kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetDeoxynucleoside kinase(Fruit fly)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314838(3'-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deo...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Drosophila melanogaster multifunctional deoxynucleoside kinase assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50314838(3'-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deo...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of human recombinant cytosolic thymidine kinase 1 assessed as inhibition of [methyl-3H]dThd phosphorylation after 30 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed