BDBM50314558 (4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(pyrazin-2-yl)methanone::CHEMBL1090016

SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1

InChI Key InChIKey=UBFOHSDZACWGDX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314558   

LigandPNGBDBM50314558((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of PDE4B3 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314558((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE4D4 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314558((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)
Affinity DataKi:  41nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314558((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)
Affinity DataKi:  8.37E+3nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed