BDBM50314556 4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)pyridazino[4,5-b]indolizin-1-amine::CHEMBL1091451

SMILES C(CNc1nnc(-c2ccccc2)c2c1cc1ccccn21)CN1CCN(CC1)c1ncccn1

InChI Key InChIKey=FGKURLWZQBUPOB-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50314556   

LigandPNGBDBM50314556(4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)pr...)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of PDE4B3 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314556(4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)pr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE4D4 expressed in CHO cells assessed as isoproterenol-induced [125I]cAMP accumulation after 15 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314556(4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)pr...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314556(4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)pr...)
Affinity DataKi:  5.90E+4nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed