BDBM50314235 CHEMBL1090995::rac-2-(5-(1-(3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)propyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-(trifluoromethyl)phenylthio)-1-morpholinoethanone

SMILES Cc1noc(n1)C1CCN(CCCn2nc(c3CN(CCc23)S(C)(=O)=O)-c2ccc(c(SCC(=O)N3CCOCC3)c2)C(F)(F)F)CC1

InChI Key InChIKey=HWGUTLJEAZNESW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314235   

TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314235(rac-2-(5-(1-(3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus expression sytem after 15 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314235(rac-2-(5-(1-(3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of invariant chain p10li after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed