BDBM50314228 (R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfonamido)-3-methylbutanamide::CHEMBL1090284

SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](C(C)C)C(=O)NO

InChI Key InChIKey=KLOYCYLPVRADHA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50314228   

TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetElastase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 56nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 29nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed