BDBM50314223 (R)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)-N-hydroxybutanamide::CHEMBL1089843
SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](CCN1C(=O)c2ccccc2C1=O)C(=O)NO
InChI Key InChIKey=MWMRJYLEVAWDDL-UHFFFAOYSA-N
Data 19 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50314223
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant ADAM10 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair