BDBM50314222 (R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate::CHEMBL1089842

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](CCNC(=O)OCc1ccccc1)C(=O)NO

InChI Key InChIKey=YAYGKNVDBLFWFW-UHFFFAOYSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50314222   

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 419nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 966nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant ADAM10 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 46nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 890nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 420nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 420nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed