BDBM50314221 (R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoindolin-2-yl)-N-hydroxybutanamide::CHEMBL1092104

SMILES ONC(=O)[C@@H](CCN1C(=O)c2ccccc2C1=O)NS(=O)(=O)c1ccc(Br)cc1

InChI Key InChIKey=MTDVSXPXWCWOED-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314221   

TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed