BDBM50313953 2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-(2-((R)-2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)propanamide::CHEMBL1091479

SMILES CC(C(=O)Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)n1nc(C)cc1C

InChI Key InChIKey=YPOOSHWMFUBQBB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313953   

TargetBeta-2 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313953(2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-(2-((R)-2-hy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313953(2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-(2-((R)-2-hy...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonistic activity at human beta3 adrenergic receptor expressed in CHO cells assessed as amount of cAMP released after 1 hr by fluorescence resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313953(2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-(2-((R)-2-hy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed