BDBM50313563 CHEMBL1077325::tert-butyl(S)-1-(2-(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo[d]imidazol-6-yl)pyrrolidin-3-ylcarbamate

SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CC[C@@H](C1)NC(=O)OC(C)(C)C

InChI Key InChIKey=LWTKJTIPCMXHIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50313563   

TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50313563(tert-butyl(S)-1-(2-(4-((S)-2-(3-chlorophenyl)-2-hy...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50313563(tert-butyl(S)-1-(2-(4-((S)-2-(3-chlorophenyl)-2-hy...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP3A4 after 20 mins by BFC fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed