BDBM50313491 (S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid::CHEMBL1078974

SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-c1sccc1-[#7]S(=O)(=O)c1cccc2nsnc12)-[#6](-[#8])=O

InChI Key InChIKey=XIWYIKLNDCZPCZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50313491   

TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 8.00E+3nMAssay Description:Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of biotinylated-VEGF-A125 from NRP1 b1 domain by cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 2.30E+4nMAssay Description:Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 7.00E+3nMAssay Description:Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNeuropilin-1(Human)
Domainex

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed