BDBM50313353 6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide::CHEMBL1080382::US9150519, 1-47

SMILES Cc1cc2[nH]ncc2cc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1

InChI Key InChIKey=YYDJCLCSBYCSCO-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50313353   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  6nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

US Patent
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  3.27E+3nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

US Patent
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  3.27E+3nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by time resolved-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed