BDBM50313336 6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)pyrimidine-4-carboxamide::CHEMBL1087142::US9150519, 1-18

SMILES Cc1cc(ccc1NC(=O)c1cc(NC2CCCCC2)ncn1)S(N)(=O)=O

InChI Key InChIKey=UUZYCNGFSOOOSO-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50313336   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50:  440nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

US Patent
LigandPNGBDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50: >3.00E+4nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 ug protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2016
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

US Patent
LigandPNGBDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50:  440nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

US Patent
LigandPNGBDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed