BDBM50313248 CHEMBL1086754::N-(3-(4-(2,3-Dichlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide::N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide hydrchloride

SMILES Cc1c(cc(-c2ccccc2)n1C)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key InChIKey=YIHQDWZWZRGAIH-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50313248   

Target5-hydroxytryptamine receptor 6(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 713nMAssay Description:Inhibition of 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 46nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 62nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5HT2C expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 984nMAssay Description:Inhibition of dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 915nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 333nMAssay Description:Inhibition of 5HT7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 54nMAssay Description:Inhibition of 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 61.7nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in HEK293 cells after 30 mins by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 46.2nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Green Cross

Curated by ChEMBL
LigandPNGBDBM50313248(N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed