BDBM50313012 10-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-3,4-dihydropyrazino[1,2-a]indole-2(1H)-carbothioamide::CHEMBL1088724::ROCHE screening, 62

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CN(CCn3c3ccccc23)C(N)=S)c2ccccc12

InChI Key InChIKey=BTWNSUFXMWNHMU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313012   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50313012(10-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihyd...)
Affinity DataIC50: 1.76E+3nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313012(10-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihyd...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50313012(10-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihyd...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed