BDBM50312994 3-(1-methyl-1H-indol-3-yl)-4-(phenylamino)-1H-pyrrole-2,5-dione::CHEMBL1086734::ROCHE screening, 39

SMILES Cn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc12

InChI Key InChIKey=JJNQVVXLJXQVLY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312994   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM50312994(3-(1-methyl-1H-indol-3-yl)-4-(phenylamino)-1H-pyrr...)
Affinity DataIC50: 231nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312994(3-(1-methyl-1H-indol-3-yl)-4-(phenylamino)-1H-pyrr...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed