BDBM50312615 2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol::CHEMBL1083508

SMILES CC(C)(O)c1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc2[nH]ncc12

InChI Key InChIKey=KYBJEPGFZBUXMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312615   

TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50312615(2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandPNGBDBM50312615(2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed