BDBM50312223 (2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo[3.3.0]octane-2-carbonitrile::CHEMBL1079474

SMILES O=C(N[C@@H]1C[C@@H]2SC[C@@H](C#N)N2C1=O)OCc1ccccc1

InChI Key InChIKey=WNQAJNNTYHSICO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50312223   

TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of poricne POP in cell lysates incubated for 60 mins using Z-Gly-Pro-AMC as a substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of POP (unknown origin) in living cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LN229 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of prolyl oligopeptidase in intact human LNZ308 cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312223((2R,5S,7R)-1-Aza-7-benzyloxycarbonylamino-8-oxo-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of POP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed