BDBM50312077 CHEMBL1087395::N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide

SMILES Oc1ccc2[nH]cc(CCNC(=O)N3CCN(CC3)c3ncccc3C(F)(F)F)c2c1

InChI Key InChIKey=FEYCSGXJKLRPJH-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50312077   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50312077(N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-4-(3-(trifluo...)
Affinity DataEC50: >2.50E+4nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50312077(N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-4-(3-(trifluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as decrease in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50312077(N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-4-(3-(trifluo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FAAH-mediated hydrolysis of [3H]AEA in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed