BDBM50311940 CHEMBL1080475::N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-tert-butylisonicotinamide

SMILES Cc1ccc(NC(=O)c2ccncc2C(C)(C)C)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1

InChI Key InChIKey=SHMSECDXWNWTEF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50311940   

TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311940(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311940(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 46nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311940(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Tel-fused LCK expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311940(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Tel-fused LYN expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311940(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 56nMAssay Description:Inhibition of Tel-fused SRC expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed