BDBM50311917 CHEMBL1079945::N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1

InChI Key InChIKey=OBLWMYNSTHSSDS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311917   

TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 661nMAssay Description:Inhibition of Tel-fused InsR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 78nMAssay Description:Inhibition of Tel-fused SRC expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 450nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 43nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Tel-fused LCK expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Tel-fused LYN expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311917(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 36nMAssay Description:Inhibition of Tel-fused KDR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed