BDBM50311561 2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)-5-methylpyrimidin-4-yloxy)benzonitrile::CHEMBL1080817

SMILES Cc1c(Oc2ccccc2C#N)ncnc1N1CCC(CC1)Oc1ncc(F)c(N)n1

InChI Key InChIKey=NKGMWVBXJYDXSK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50311561   

TargetDeoxycytidine kinase(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311561(2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)
Affinity DataEC50:  54nMAssay Description:Inhibition of dCK in human CCRF-CEM assessed as inhibition of Ara-C phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetDeoxycytidine kinase(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311561(2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed