BDBM50311518 CHEMBL1087150::N-(4-chlorobenzyl)-2-((2R,6R,E)-5,13-dioxo-2-phenyl-1-oxa-4-azacyclotridec-8-en-6-yl)acetamide

SMILES Clc1ccc(CNC(=O)C[C@H]2C\C=C\CCCC(=O)O[C@@H](CNC2=O)c2ccccc2)cc1

InChI Key InChIKey=VJOZJBFMGBVMBJ-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50311518   

TargetSonic hedgehog protein(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311518(N-(4-chlorobenzyl)-2-((2R,6R,E)-5,13-dioxo-2-pheny...)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSonic hedgehog protein(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50311518(N-(4-chlorobenzyl)-2-((2R,6R,E)-5,13-dioxo-2-pheny...)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells after 30 hrs by GLI-responsive bright glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed