BDBM50311467 CHEMBL1080990::ethyl 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methyl-6H-pyrrolo[3,4-d]pyridazine-5-carboxylate

SMILES CCOC(=O)c1[nH]c(C)c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12

InChI Key InChIKey=NURBYSCFSBBMLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50311467   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(ethyl 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50: 934nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(ethyl 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(ethyl 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed