BDBM50311465 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(2-morpholinoethyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide::CHEMBL1080506

SMILES Cc1c([nH]c2cnnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c12)C(=O)NCCN1CCOCC1

InChI Key InChIKey=CDDJNPZYBJNIRP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311465   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: 4nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed