BDBM50311245 (S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)thiazole-5-carboxamide::CHEMBL1078675

SMILES Cc1nc(sc1C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1)-c1ccccc1

InChI Key InChIKey=YYKAPLBODOAMOB-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50311245   

TargetCruzipain(Trypanosoma cruzi)
University of California

Curated by ChEMBL
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin B-like cysteine protease(Trypanosoma brucei)
University of California

Curated by ChEMBL
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Trypanosoma brucei Cathepsin B-like protease after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal Do Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataKi:  6nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris measured for 30 mins using Cbz-Phe-Arg-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal Do Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataKi:  320nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed