BDBM50310923 CHEMBL1077943::US9120807, 6::{6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidin-4-yl}-thiophen-2-yl-methanone

SMILES CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1

InChI Key InChIKey=RMJSDWIAVCAAMH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50310923   

TargetAdenosine receptor A1(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 57.6nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 277nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 1.40nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
Go to US Patent

TargetAdenosine receptor A3 [I248L](Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 22.9nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310923({6-Methylamino-2-[(pyridin-3-ylmethyl)-amino]-thie...)
Affinity DataIC50: 965nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed