BDBM50310739 (S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbonyl)-4-methylpiperidin-4-yl)-3-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-3,9-diazaspiro[5.5]undecan-2-one::CHEMBL1078231

SMILES CCCC[C@H]1CN(CC2CCOCC2)C(=O)OC11CCN(CC1)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C

InChI Key InChIKey=CXXVJZRGOOIVOD-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50310739   

TargetC-C chemokine receptor type 5(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CCR2b receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CCR3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CCR4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 6(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CCR6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to human CXCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50310739((S)-5-butyl-9-(1-(4,6-dimethylpyrimidine-5-carbony...)
Affinity DataIC50: 4nMAssay Description:Displacement of [128I]-RANTES from CCR5 receptor receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed