BDBM50310474 4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine::CHEMBL1079135

SMILES Cc1ccc2n(C3CCC3)c(nc2c1)-c1nonc1N

InChI Key InChIKey=WJBVKTYQLWGNGE-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50310474   

TargetRibosomal protein S6 kinase beta-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p70S6 (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Treventis

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  19nMAssay Description:Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed