BDBM50310454 4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine::CHEMBL1079208

SMILES CC(C)n1c(nc2ccccc12)-c1nonc1N

InChI Key InChIKey=OOQLAKYHQPZMKP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310454   

TargetRibosomal protein S6 kinase beta-1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310454(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  40nMAssay Description:Inhibition of p70S6K assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310454(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of GSK3-beta assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310454(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of ROCK1 assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310454(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxa...)
Affinity DataKi: >3.30E+3nMAssay Description:Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence ofMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed