BDBM50309961 CHEMBL3217125::N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-methyl-1H-imidazole-4-carboxamide dihydrochloride

SMILES Cn1cnc(c1)C(=O)N(Cc1cccc(Cl)c1)[C@@H]1CC[C@H](N)CC1

InChI Key InChIKey=DNRRPNHABAPADP-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50309961   

LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human glycine transporter 2-mediated glycine uptake expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataIC50: 6.56E+4nMAssay Description:Inhibition of human ERG by patch clamp studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataKi:  1.80nMAssay Description:Displacement of tritiated NPTS from human glycine transporter 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50309961(N-((cis)-4-aminocyclohexyl)-N-(3-chlorobenzyl)-1-m...)
Affinity DataKi:  3.76E+3nMAssay Description:Displacement of radiolabeled dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed