BDBM50309831 10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11-dione::CHEMBL596657

SMILES O=c1nc2oc3ccc4ccccc4c3cc2c(=O)n1-c1ccccc1

InChI Key InChIKey=KIPCUWCLMUBIQX-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50309831   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.91E+5nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli incubated at 37 degC for 2 hrs by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.91E+5nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli incubated at 37 degC for 2 hrs by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.91E+5nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli using Fluor de Lys substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli using Fluor de Lys substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of recombinant human SIRT1 expressed in Escherichia coli using Fluor de Lys-SIRT1/2 substrate in presence of NAD+ by fluorescence micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Istituto Ortopedico Rizzoli (Ior)

Curated by ChEMBL
LigandPNGBDBM50309831(10-Phenyl-7-oxa-8,10-diaza-benzo[a]anthracene-9,11...)
Affinity DataIC50: 1.91E+5nMAssay Description:Inhibition of recombinant human SIRT2 expressed in Escherichia coli using Fluor de Lys-SIRT1/2 substrate in presence of NAD+ by fluorescence micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed