BDBM50309126 2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-2-yl)piperazin-1-yl)ethanol::CHEMBL599163

SMILES OCCN1CCN(CC1)c1nc(cnc1N1CCCC1)-c1ccncc1

InChI Key InChIKey=AMYLYHGYASWELD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50309126   

TargetRho-associated protein kinase 1(Human)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50: 570nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataEC50:  680nMAssay Description:Inhibition of ROCK-2 in human GTM3 cells measured up to 2 days by cell impedance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed