BDBM50308702 5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbonyl]-piperidin-4-yl}-2-(trifluoromethyl)benzenesulfonamide::CHEMBL591482

SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCNC1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=GMKQKEGOSSISFQ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308702   

TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308702(5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbo...)
Affinity DataEC50:  380nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308702(5-(Phenylsulfonyl)-N-{1-[(3R)-pyrrolidin-3-ylcarbo...)
Affinity DataIC50: 60nMAssay Description:Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed