BDBM50308696 CHEMBL590312::tert-Butyl 4-{2-oxo-2-[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]ethyl}piperidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCC(CC(=O)N2CCC(CC2)NS(=O)(=O)c2cc(ccc2C(F)(F)F)S(=O)(=O)c2ccccc2)CC1

InChI Key InChIKey=RGUYWJIIGGMBKL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50308696   

TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308696(tert-Butyl 4-{2-oxo-2-[4-({[5-(phenylsulfonyl)-2-(...)
Affinity DataEC50:  400nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50308696(tert-Butyl 4-{2-oxo-2-[4-({[5-(phenylsulfonyl)-2-(...)
Affinity DataIC50: 490nMAssay Description:Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed