BDBM50308512 (5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one::CHEMBL603830::[R]-Mesopram

SMILES CCCOc1cc(ccc1OC)[C@@]2(CNC(=O)O2)C

InChI Key InChIKey=PCCPERGCFKIYIS-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308512   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308512((5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-ox...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308512((5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-ox...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308512((5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-ox...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)