BDBM50308189 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benz-azepin-6-one::CHEMBL598000

SMILES Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl

InChI Key InChIKey=NKTDDFFCFNHRMA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308189   

TargetSerine/threonine-protein kinase PLK1(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308189(2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308189(2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308189(2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of VEGFR2 in HUE cells assessed as inhibition of VEGF-induced autophosphorylation treated for 90 mins before VEGF challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308189(2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrim...)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed