BDBM50308188 2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one::CHEMBL603463

SMILES COc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1O

InChI Key InChIKey=SRLAWDYDLHMAMZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50308188   

TargetAurora kinase B(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant Aurora B using tetra(LRRWSLG) as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of VEGFR2 in HUE cells assessed as inhibition of VEGF-induced autophosphorylation treated for 90 mins before VEGF challenge by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 73nMAssay Description:Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant FAK using poly(Glu,Tyr)4 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 73nMAssay Description:Inhibition of recombinant VEGFR2 using poly(Glu,Tyr)4 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant PLK1 using RBERCHKtide as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308188(2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyri...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant AKT1 using GSK3 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 mins by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed