BDBM50308134 4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)methyl]benzoic acid::CHEMBL601299

SMILES OC(=O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1

InChI Key InChIKey=BGASCMMYJZPCSS-UHFFFAOYSA-N

Data  10 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50308134   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation counting in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi:  0.900nM ΔG°:  -12.3kcal/molepH: 6.0 T: 2°CAssay Description:Transfected HEK 293(ebna) cells are maintained in culture, harvested and membranes are prepared by differential centrifugation, following lysis of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]PGD2 from human DP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstacyclin receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]iloprost from human IP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]SQ29548 from human TP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Affinity DataKi: >628nMAssay Description:Displacement of [3H]PGF2alpha from human FP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed