BDBM50308122 2-(tert-butylamino)-1-(3-methoxyphenyl)propan-1-one::CHEMBL603620

SMILES COc1cccc(c1)C(=O)C(C)NC(C)(C)C

InChI Key InChIKey=DGQVZUDAKWRJPY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308122   

TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308122(2-(tert-butylamino)-1-(3-methoxyphenyl)propan-1-on...)
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308122(2-(tert-butylamino)-1-(3-methoxyphenyl)propan-1-on...)
Affinity DataIC50: 100nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308122(2-(tert-butylamino)-1-(3-methoxyphenyl)propan-1-on...)
Affinity DataIC50: 100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308122(2-(tert-butylamino)-1-(3-methoxyphenyl)propan-1-on...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed