BDBM50308116 2-(N-Pyrrolidinyl)-3'-fluoropropiophenone::CHEMBL599028

SMILES CC(N1CCCCC1)C(=O)c1cccc(F)c1

InChI Key InChIKey=UDGISDAHRCDXMV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308116   

TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308116(2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | CHEMBL...)
Affinity DataIC50: 100nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308116(2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | CHEMBL...)
Affinity DataIC50: 135nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308116(2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | CHEMBL...)
Affinity DataIC50: 156nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50308116(2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | CHEMBL...)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed