BDBM50308104 CHEMBL590552::N-{3-[4-(4-Isopropyl-pheny)-2-oxo-6-propargyloxy-2H-quinazolin-1-ylmethyl]-phenyl}-2-[4-(2-methoxy-ethyl)piperazin-1-yl]-acetamide

SMILES COCCN1CCN(CC(=O)Nc2cccc(Cn3c4ccc(OCC#C)cc4c(nc3=O)-c3ccc(cc3)C(C)C)c2)CC1

InChI Key InChIKey=ORDNSHRYPJOLOS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308104   

TargetExtracellular calcium-sensing receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308104(N-{3-[4-(4-Isopropyl-pheny)-2-oxo-6-propargyloxy-2...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed