BDBM50307987 CHEMBL604712::N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamide

SMILES CC(C)(C)C(=O)N1Cc2c(NC(=O)c3cc(F)cc(F)c3)[nH]nc2C1(C)C

InChI Key InChIKey=QXBKFUBBGBWPCJ-UHFFFAOYSA-N

Data  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50307987   

TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cKit by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NEK6 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDC7 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 450nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of CDK2/cyclin E by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 3.63E+3nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-ABL by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR3 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307987(N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed