BDBM50307884 3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)BIPHENYL-4-YL SULFAMATE::5'-((1H-1,2,4-Triazol-1-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl Sulfamate::CHEMBL592131

SMILES c1cc(c(cc1Cn2cncn2)c3ccc(c(c3)Cl)OS(=O)(=O)N)C#N

InChI Key InChIKey=ZUTFDMVDCHXOFA-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50307884   

TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of STS activity (unknown origin) expressed in JEG-3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 86nMAssay Description:Inhibition of carbonic anhydrase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of aromatase (unknown origin) expressed in JEG-3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione after 1 hr by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of steroid sulfatase in human JEG-3 cells using [6,7-3H]E1S after 1 hr by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human CA2 by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of aromatase in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of steroid sulfatase in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed